49ers vs Cardinals prediction: what pundits picked
San Francisco 49ers at Arizona Cardinals · Week 18, 2026 · Sun, Jan 10
No pundit we track has picked a side in 49ers vs Cardinals yet.
49ers at Cardinals: how they come in
The 49ers are 4-0 and have won 4 straight; the Cardinals are 1-3 and have lost 3 straight. The 49ers beat the Cardinals 36-30 when they met in Week 3. On win totals, 12 pundits put the 49ers at 9.8 wins on average, and 8 pundits put the Cardinals at 4.2 wins on average.
State Farm Stadium, Glendale, Arizona · Division game
- Record
- 4-0 · won 4 straight · 122 scored, 64 allowed
- Last games
- W 24-14 vs Broncos Week 4
- W 36-30 vs Cardinals Week 3
- W 35-13 vs Dolphins Week 2
- Unit ranks
- offense 2nd, defense 6th of 32 (this season)
- Last season
- 12-5
- Win-total calls
- 12 pundits · average 9.8 · 3 to 13 wins
- The room's picks
- the side most pundits took won 3 of 4 49ers games
- Record
- 1-3 · lost 3 straight · 87 scored, 117 allowed
- Last games
- L 24-36 at Giants Week 4
- L 30-36 at 49ers Week 3
- L 7-31 vs Seahawks Week 2
- Unit ranks
- offense 22nd, defense 30th of 32 (this season)
- Last season
- 3-14
- Win-total calls
- 8 pundits · average 4.2 · 1 to 9 wins
- The room's picks
- the side most pundits took won 2 of 4 Cardinals games
Earlier this season: Cardinals 30, 49ers 36 (Week 3)
49ers and Cardinals players to watch
Each club’s starting quarterback, leading rusher, receiver and tight end, and its sack and tackle leaders, with their 2026 regular season so far, with the latest call on each from a pundit on our leaderboard whose record beats the naive pick (42 pundits clear that bar), made since the 2026 schedule came out. “No.” is their rank there.
49ers
- Brock PurdyStarting QB · QB
1,007 passing yards · 11 TD, 1 INT · 69.9% completions · 122 rushing yards · 4 games · 12th in the NFL in passing yards
Brock Purdy to finish top 12 at his position, by fantasy points
“Consider him a low-end QB1 in 2026 fantasy drafts.” the article →
Brock Purdy to finish top 12 at his position, by fantasy points
“Purdy will again be a QB1 that goes far too late in drafts in 2026.” the article →
- Christian McCaffreyRB1 · RB
218 rushing yards on 50 carries · 4 TD · 16 catches for 122 · 4 games · 21st in the NFL in rushing yards
Christian McCaffrey to outplay his draft cost (that mid first round pick)
“Pat has them ranked number seven overall... So I think we just need to get like twelve or thirteen games, fourteen games out of him to have him be worth that mid first round pick... that's why I'm willing to draft Christian McCaffrey in the middle of the first round.” the article →
Christian McCaffrey to make the roster
“So Christian McCaffrey, Kyle Youssek locked in. Kalyn Black locked in. Jordan James locked in.” the article →
- Mike EvansWR1 · WR
17 catches for 213 yards · 2 TD · 4 games · 36th in the NFL in receiving yards
Mike Evans to be 1st on the depth chart
“Free-agent addition Mike Evans is expected to be Purdy's new No. 1 receiver” the article →
Mike Evans to outplay his draft cost (a locked and loaded top twenty four guy)
“I'm drafting him, and I think he's gonna boom. I think he's gonna boom in this offense” the article →
- George KittleTE1 · TE
16 catches for 244 yards · 4 TD · 4 games · 19th in the NFL in receiving yards
George Kittle to make the roster
“I got three tight ends here. George Kittle, who is no longer gonna be on Pup, so he has to make the roster.” the article →
George Kittle — “playing week one”
“More likely future hall of famer to play week one. George Kittle or Patrick Mahomes? ... Both are playing week one.” the article →
- Keion WhiteSack leader · DE
2 sacks · 2 solo tackles · 4 games · 26th in the NFL in sacks
Keion White to make the roster
“It's gonna be Samuel Kwan who is gonna be Kean White, and it's going to be Romello Hite.” the article →
- Fred WarnerTackle leader · LB
0.5 sacks · 17 solo tackles · 4 games · 26th in the NFL in solo tackles
Fred Warner to make All-Pro
“my preseason All-Pro team ... Linebacker: Fred Warner, San Francisco 49ers” the article →
Fred Warner to make the roster
“We know that Fred Warner is gonna make the roster.” the article →
Cardinals
- Jacoby BrissettStarting QB · QB
818 passing yards · 6 TD, 4 INT · 67.8% completions · 4 games · 20th in the NFL in passing yards
Jacoby Brissett to be 1st on the depth chart
“if they stay competitive i think we see brissette for the rest of the year are barring an injury like i don't think carson beck is is a long-term answer quarterback” the article →
Jacoby Brissett to be 1st on the depth chart
“Brissett remains the starter as an added positive” the article →
- Jeremiyah LoveRB1 · RB
223 rushing yards on 55 carries · 2 TD · 11 catches for 36 · 4 games · 19th in the NFL in rushing yards
Jeremiyah Love to be 1st on the depth chart
“Most likely, it will be only a week or two before Love relegates Allgeier to a much smaller role.” the article →
Jeremiyah Love to finish RB3 (25–36) at his position, by fantasy points
“I have him as an RB3, and when it all shakes out, that's where he's going to be, somewhere in that RB3 range.” the article →
- Michael WilsonWR1 · WR
25 catches for 258 yards · 1 TD · 4 games · 17th in the NFL in receiving yards
Michael Wilson to be 1st on the depth chart
“Wilson is just entering his prime and could potentially become a No.1 receiver.” the article →
Michael Wilson to be 2nd on the depth chart
“Michael Wilson is the clear number two option in the Arizona passing attack as the WR21 in fantasy points per game.” the article →
- Trey McBrideTE1 · TE
33 catches for 242 yards · 2 TD · 4 games · 20th in the NFL in receiving yards
Trey McBride to fall short of his draft cost (a top-20 ADP)
“Trey McBride has a top-20 ADP... his target volume and touchdown total are both strong candidates to regress. He may still play well without delivering the type of production needed to justify selecting him in the middle of the second round.” the article →
Trey McBride to fall short of his draft cost (the second round of non-TE Premium drafts)
“they are why I would suggest he is not someone I would pull the trigger on in the second round of non-TE Premium drafts... Even with McBride having the best odds to run the most routes again, I am not drafting him at his current cost” the article →
- Budda BakerSack leader · Tackle leader · S
1.5 sacks · 14 solo tackles · 1 interception · 4 games · 53rd in the NFL in sacks · 64th in the NFL in solo tackles
Who the room took
No pundit we track has picked a side yet.
Every call on 49ers at Cardinals
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